Ph D Scholarship In Metabolism And Cancer Biology

at University of Melbourne

Summary

The Department of Physiology at the University of Melbourne and the Prostate Cancer Research Group of the Biomedicine Discovery Institute at Monash University are seeking a PhD student to undertake a groundbreaking project funded by the Cancer Council of Victoria.

Prostate cancer is the most commonly diagnosed cancer in men, and accounts for 13% of cancer-related deaths in Australian men. There is currently no cure for advanced stage prostate cancer and a major clinical challenge is to improve the efficacy of existing therapies or discover new strategies for intervention.

The successful applicant will be embedded in a collegial team environment with combined expertise in the study of metabolism and cancer biology, using state-of-the-art facilities in mass spectrometry, metabolomics, single cell RNA-Seq and mouse phenotyping.

The project will explore the molecular and functional methods to study the regulation of metabolism and cancer progression in a variety of pre-clinical experimental models of prostate cancer including organoids and patient-derived xenografts. The project will extend on recent pre-clinical work from our laboratories (Watt et al. Science Translational Medicine 11 (478), 2019) with discovery and translation being the primary focus.

Institution

Melbourne University's global aspirations seek to make significant contributions to major social, economic and environmental challenges. Accordingly, the University's research strategy Research at Melbourne: Ensuring Excellence and Impact to 2025 aspires to a significant advancement in the excellence and impact of its research outputs. See: http://research.unimelb.edu.au/our-research/research-at-melbourne

Department of Physiology

https://biomedicalsciences.unimelb.edu.au/departments/physiology

The working environment

The project will be jointly conducted in the Biology of Lipid Metabolism laboratory within the Department of Physiology at the University of Melbourne and the Prostate Cancer Research Group of the Biomedicine Discovery Institute at Monash University. Our team brings combined expertise in the study of metabolism and cancer biology. We use cutting edge molecular and functional methods to study the regulation of metabolism and cancer progression in a variety of pre-clinical experimental models of prostate cancer including organoids and patient-derived xenografts. We have access to state-of-the-art facilities in mass spectrometry, metabolomics, single cell RNA-Seq and mouse phenotyping, and maintain close links with clinical collaborators in urology, pathology and oncology.

The project- "Targeting lipid metabolism for prostate cancer therapy"

Prostate cancer is the most commonly diagnosed cancer in men, and accounts for 13% of cancer-related deaths in Australian men. There is currently no cure for advanced stage prostate cancer and a major clinical challenge is to improve the efficacy of existing therapies or discover new strategies for intervention. This project is funded by the Cancer Council Victoria and will focus on understanding metabolism in prostate cancer to develop new therapies to slow prostate cancer growth. The candidate will apply advanced methodologies for the assessment of metabolism with genetic and pharmacological interventions in clinically relevant models of prostate cancer. The project will extend on recent pre-clinical work from our laboratories (Watt et al. Science Translational Medicine 11 (478), 2019) with discovery and translation being the primary focus. The outcomes of this PhD project will provide the advance in knowledge and the first steps to strategically advance novel metabolic therapies beyond laboratory-based concept to clinical development.

The person

Applicants will have a First-Class Honours degree or equivalent and should be eligible for an Australian Postgraduate Award (APA) or equivalent. Basic expertise and experience in biomedicine or other relevant biological sciences is required, and students with experience in cancer biology and/or metabolism are especially encouraged to apply. Applicants must fulfil the PhD admission criteria for the University of Melbourne, including meeting English language requirements, and demonstrating excellent capacity and potential for research. Demonstration of research ability through publication output in peer reviewed international journals is desirable. Further information on entry requirements: https://study.unimelb.edu.au/find/courses/graduate/doctor-of-philosophy-medicine-dentistry-and-health-sciences/

You must have the right to live and work in this location to apply for this scholarship.

Remuneration

Annual stipend $30,600 (indexed, 2019 rate) for 3 years with the possibility of a 6 month extension

Enquiries

For all enquiries, please contact: * Prof Matthew Watt (matt.watt@unimelb.edu.au) or * A/Prof. Renea Taylor (renea.taylor@monash.edu)

How to apply

Please do not apply via the University advertisement. All applicants must apply via email to Lill Gardner at: physiology-info@unimelb.edu.au with the subject title: APPLICATION PhD Scholarship - Your name. In your email please attach the following documents: * A cover letter stating your skills and experiences, areas of expertise, and compelling reasons for wanting to pursue PhD studies in this program; * Your complete Academic Records (including grades/GPA scores, and grading scale details) * CV/Resume Short-listed candidates will be contacted for a meeting with Prof Matthew Watt and A/Prof Renea Taylor to discuss your application and the project in more detail. If successful you will be instructed to submit an application to the Graduate School for admission.

Position Description

Download File 899302.pdf

Expression of Interest Close Date: 25 April 2019

Parkville Victoria Australia
FULL_TIME
2019-03-28
2019-04-26

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